Subject: Table 1: International Panel Criteria (McDonald Criteria) for Diagnosis MS
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Date: Fri, 2 May 2008 11:10:34 -0600

Table 1:

International Panel Criteria (McDonald Criteria) for Diagnosis
MS

Clinical
Presentation

Additional Data Needed for MS
Diagnosis

Two or more attacks; objective clinical evidence of 2 or more
lesions

Nonea

Two or more attacks; objective
clinical evidence of 1 lesion

Dissemination in space
demonstrated by:

MRIb, or

2 or more MRI
lesions consistent with MS plus positive CSFc, or

await further
clinical attack implicating a different site.

One attack; objective clinical
evidence of 2 or more lesions

Dissemination in time
demonstrated by:

MRIb, or

second clinical
attack.

One attack; objective clinical
evidence of 1 lesion (clincally isolated syndrome)

Dissemination in space
demonstrated by:

MRIb,
or

2 or more MRI
lesions consistent with MS plus positive CSFc

And dissemination in
time, demonstrated by:

MRIb, or

Second clinical
attack

Insidious neurological
progression suggestive of MS

Positive
CSFc, and dissemination in space,
demonstrated
by:

1) 9 or more T2 lesions in
brain, or 2) 2 or more lesions in spinal cord, or 3) 4-8 brain lesions plus 1
spinal cord lesion; or

Abnormal visual
evoked potentials with MRI demonstrating 4-8 brain lesions, or fewer
than 4 brain lesions plus 1 spinal cord lesion; and

Dissemination in
time demonstrated by MRIb; or

Continued
progression for 1 year

a Brain MRI
is recommended to exclude other etiologies
b MRI criteria
for dissemination in space or time are described in Table
2
c Positive CSF defined as oligoclonal bands
different from those in serum, or raised IgG index.
Adapted from
reference 6.

Copyright 2002 The Cleveland Clinic
Foundation

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