From: Subject: Table 1: International Panel Criteria (McDonald Criteria) for Diagnosis MS Date: Fri, 2 May 2008 11:10:34 -0600 MIME-Version: 1.0 Content-Type: text/html; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.clevelandclinicmeded.com/medicalpubs/diseasemanagement/neurology/multsclerosis/table1ms.htm X-MimeOLE: Produced By Microsoft MimeOLE V6.00.2900.3198 Table 1: International Panel Criteria (McDonald = Criteria) for Diagnosis MS
Table 1:
International Panel Criteria (McDonald Criteria) for = Diagnosis=20 MS
Clinical=20 Presentation
Additional Data = Needed for MS=20 Diagnosis
Two or more attacks; objective clinical evidence of 2 or = more=20 lesions Nonea
Two or more = attacks; objective=20 clinical evidence of 1 lesion

Dissemination in space=20 demonstrated by:

  • MRIb, or
  • 2 or = more MRI=20 lesions consistent with MS plus positive CSFc, = or=20
  • await = further=20 clinical attack implicating a different site. =
One attack; = objective clinical=20 evidence of 2 or more lesions

Dissemination in time=20 demonstrated by:

  • MRIb, or
  • second = clinical=20 attack.
One attack; = objective clinical=20 evidence of 1 lesion (clincally isolated syndrome)

Dissemination in = space=20 demonstrated by:

  • MRIb,=20 or=20
  • 2 or = more MRI=20 lesions consistent with MS plus positive CSFc =

And = dissemination in=20 time, demonstrated by:

  • MRIb, or=20
  • Second = clinical=20 attack
Insidious = neurological=20 progression suggestive of MS

Positive=20 CSFc, and dissemination in space,
demonstrated=20 by:

  • 1) 9 or more T2 = lesions in=20 brain, or 2) 2 or more lesions in spinal cord, or 3) = 4-8 brain lesions = plus 1=20 spinal cord lesion; or=20
  • Abnormal visual=20 evoked potentials with MRI demonstrating 4-8 brain lesions, or = fewer=20 than 4 brain lesions plus 1 spinal cord lesion; and =
  • Dissemination in=20 time demonstrated by MRIb; or=20
  • Continued=20 progression for 1 year

a Brain MRI=20 is recommended to exclude other etiologies
b MRI = criteria=20 for dissemination in space or time are described in Table=20 2
c Positive CSF defined as oligoclonal = bands=20 different from those in serum, or raised IgG index.
Adapted = from=20 reference 6.

Copyright 2002 The Cleveland Clinic=20 Foundation

Return=20 to Multiple Sclerosis Chapter